Effects of Fructus Akebiae on learning and memory impairment in a scopolamine-induced animal model of dementia

نویسندگان

  • JINGHUA WANG
  • XUAN WANG
  • BAOSHENG LV
  • WEIXIU YUAN
  • ZEGUO FENG
  • WEIDONG MI
  • HONG ZHANG
چکیده

Fructus Akebiae (FAE) is a component of traditional Chinese medicines used for the clinical treatment of amnesia. The aim of the present study was to investigate the effects of FAE extract on scopolamine-induced learning and memory impairment in mice and Sprague-Dawley rats. Treatment with FAE (2.5, 5 and 10 mg/kg) was investigated in scopolamine-treated animals, and its effects on different types of memory were examined using the T-maze, the Morris water maze task, the novel object recognition test, the passive avoidance task and the step-down test. The results revealed that 5 and 10 mg/kg FAE attenuated scopolamine-mediated impairment of cognition, including spatial, episodic, aversive, and short- and long-term memory. Overall, these results suggest that FAE is an effective cognitive enhancer, and thus highlights the value of a multi-target strategy to address the complexity of cognitive dysfunction in Alzheimer's disease.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Effects of oleuropein on malondialdehyde level and expression of GluN2B gene following passive avoidance memory impairment in mice

Introduction: Oleuropein is the most important phenolic compound in olive leaves which has several pharmacological properties. So far, this compound has been shown to have antioxidant, anti-inflammatory, anti-atrogenic, antimicrobial, and antiviral properties. Scopolamine is a muscarinic antagonist used as standard medication for inducing cognitive deficits in humans and animals. This study was...

متن کامل

The effect of intracerebroventricular administration of insulin on memory impairment-induced by scopolamine in male rats

Introduction: Cholinergic neuronal deficiency is one of the main causes of Alzheimer's pathology, which leads to learning and memory impairment. Scopolamine is a muscarinic cholinergic antagonist commonly used to induce Alzheimer's disease (AD). Insulin also regulates learning and memory function. Thus, the aim of this study was to determine the effect of central administration of insulin on pa...

متن کامل

The effect of Crocin on scopolamine induced spatial learning and memory deficits in rats

Introduction: The cholinergic system plays an important role in learning and memory. Administration of either extracts of Crocus Sativus (Saffron) or its constituent, crocin, reduced ethanol-induced memory impairment. Based on the above findings, we investigated the effect of crocin in antagonizing spatial learning and memory impairment induced by scopolamine, a cholinergic receptor antagoni...

متن کامل

Effects of Different Coumarin- 3-Carboxamide Agents on Scopolamine Induced Learning and Memory Deficit in Mice

Introduction: It has been shown that three new synthetic coumarins-3-carboxamides including 3-fluorobenzilchloride, 4-fluorobenzilchloride and 2-hidroxy-3 metoxybenzaldehyde, have acetylcholinesterase inhibitory activity. This study was performed to estimate ameliorating effect of these new coumarin-3-carboxamides on memory impairments induced by scopolamine (1 mg/kg, induced prolongation) in m...

متن کامل

بررسی تاثیر عصاره‌ی آبی سنجد بر اختلال حافظه ایجاد شده توسط اسکوپولامین در موش‌های صحرایی

Background and Objective: Impaired cognitive function and memory, a characteristic of Alzheimer's disease, can be caused by decreased activity of the cholinergic system. Scopolamine, a muscarinic receptor antagonist, may cause temporary impairment in memory and provide an Alzheimer's disease model. This study was designed to evaluate the effects of water extract of Elaeagnus Angustifolia on mem...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 8  شماره 

صفحات  -

تاریخ انتشار 2014